New capabilities of laboratory diagnosis of thromboses

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Abstract

The growing number of thromboses has been observed in various fields of medicine, which makes the issues of early diagnosis and investigation of thrombotic condition predictors more topical. Evaluation of hemostasis and investigation of risk factors of both thrombotic and hemorrhagic states is one of the most complex diagnostic problems. The objectives of laboratory diagnosis include not only studying of already known indicators of thrombovascular hemostasis and standard coagulation tests but also developing, automating, and improving of new methods for detection of biomarkers of hemostasis disturbances. According to the results of modern research, a high level of the subpopulation of procoagulant or coated platelets, known as COAT-platelets, in patient blood can be considered as this new marker for predicting thrombosis. COAT-platelets are a subpopulation of collagen and thrombin-activated platelets maintaining a high procoagulant activity of blood.

 

About the authors

Alla A. Shabalina

Research Center of Neurology

Author for correspondence.
Email: ashabalina@yandex.ru
ORCID iD: 0000-0001-9604-7775

D. Sci. (Med.), leading researcher, Head, Laboratory of hemorheology, hemostasis and pharmacokinetics (with clinical laboratory diagnostics)

Russian Federation, Moscow

M. V. Kostyreva

Research Center of Neurology

Email: ashabalina@yandex.ru
Russian Federation, Moscow

Marine M. Tanashyan

Research Center of Neurology

Email: ashabalina@yandex.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

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Copyright (c) 2015 Shabalina A.A., Kostyreva M.V., Tanashyan M.M.

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