Features of atherosclerosis of the cerebral arteries and pathomorphology of cerebral infarctions in patients with type 2 diabetes mellitus
- Authors: Anufriev P.L.1, Tanashyan M.M.1, Gulevskaya T.S.1, Ablyakimov R.E.1, Gnedovskaya E.V.1
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Affiliations:
- Research Center of Neurology
- Issue: Vol 9, No 3 (2015)
- Pages: 4-9
- Section: Original articles
- Submitted: 01.02.2017
- Published: 09.02.2017
- URL: https://www.annaly-nevrologii.com/journal/pathID/article/view/143
- DOI: https://doi.org/10.17816/psaic143
- ID: 143
Cite item
Full Text
Abstract
Comparison of the results of 20 autopsy cases of ischemic strokes developed during atherosclerosis with 20 autopsy cases of ischemic strokes associated with atherosclerosis in combination with type 2 diabetes mellitus (T2DM) provided data indicating a high significance of T2DM in the development of severe changes in the cerebral arteries, causing cerebral infarctions of various size and localization. A significant prevalence in the number of atherosclerotic plaques in the cerebral arteries, including those causing stenosis of the lumen by 50% or more, was found in the case of T2DM compared to cases without T2DM. Cerebral infarctions in T2DM were mostly of the multiple nature that was determined by a combination of fresh or organizing extensive, large or medium, infarction with one/several organized medium, small deep, and small surface infarctions. More severe atherosclerosis of the cerebral arteries in T2DM caused a higher rate of infarctions due to occlusive atherothrombosis, arterio-arterial embolism, and tandem atherostenosis in these patients compared to cases without T2DM. In the absence of T2DM, infarctions occurred more often due to embolism of the cerebral arteries from the heart with coronary heart disease compared to cases with T2DM.
About the authors
Pavel L. Anufriev
Research Center of Neurology
Email: anufriev@neurology.ru
ORCID iD: 0000-0002-5327-2275
Cand. Sci. (Med.), senior researcher, Laboratory of neuromorphology
Россия, 125367, Moscow, Volokolamskoye shosse, 80Marine M. Tanashyan
Research Center of Neurology
Email: anufriev@neurology.ru
ORCID iD: 0000-0002-5883-8119
D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department
Россия, MoscowTatyana S. Gulevskaya
Research Center of Neurology
Email: anufriev@neurology.ru
ORCID iD: 0000-0003-2970-8136
D. Sci. (Med.), Prof., chief researcher, Laboratory of neuromorphology
Россия, 125367, Moscow, Volokolamskoye shosse, 80Renat E. Ablyakimov
Research Center of Neurology
Email: anufriev@neurology.ru
Россия, Moscow
Elena V. Gnedovskaya
Research Center of Neurology
Author for correspondence.
Email: anufriev@neurology.ru
Россия, Moscow
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