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Mapping of the brain regions responsible for eating behavior regulation with functional MRI
- Authors: Kremneva E.I.1, Suslin A.S.1, Govorin A.N.1, Krotenkova M.V.1, Tanashyan M.M.1, Piradov M.A.1
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Affiliations:
- Research Center of Neurology
- Issue: Vol 9, No 1 (2015)
- Pages: 32-36
- Section: Technologies
- URL: https://www.annaly-nevrologii.com/journal/pathID/article/view/156
- DOI: https://doi.org/10.17816/psaic156
- ID: 156
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Abstract
Understanding the neural mechanisms underlying the regulation of eating behavior plays the leading role in assessment of food intake in normal individuals and in patients with obesity. Modern neuroimaging methods, such as functional MRI (fMRI), may shed the light on these mechanisms. A simple and reproducible visual fMRI-paradigm was developed for the assessment of topdown executive control of eating behavior. Using this paradigm, three main components of the regulatory neural system were revealed, and the region of interest, dorsolateral prefrontal cortex, was identified.
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About the authors
Elena I. Kremneva
Research Center of Neurology
Author for correspondence.
Email: kremneva@neurology.ru
ORCID iD: 0000-0001-9396-6063
Cand. Sci. (Med.), radiologist, senior researcher, Neuroradiology department
Russian Federation, 125367, Moscow, Volokolamskoye shosse, 80Aleksander S. Suslin
Research Center of Neurology
Email: kremneva@neurology.ru
Russian Federation, Moscow
A. N. Govorin
Research Center of Neurology
Email: kremneva@neurology.ru
Russian Federation, Moscow
Marina V. Krotenkova
Research Center of Neurology
Email: kremneva@neurology.ru
ORCID iD: 0000-0003-3820-4554
D. Sci. (Med.), Head, Radiology department
Russian Federation, 125367, Russia, Moscow, Volokolamskoye shosse, 80Marine M. Tanashyan
Research Center of Neurology
Email: kremneva@neurology.ru
ORCID iD: 0000-0002-5883-8119
D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department
Russian Federation, MoscowMikhail A. Piradov
Research Center of Neurology
Email: kremneva@neurology.ru
ORCID iD: 0000-0002-6338-0392
D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director
Russian Federation, MoscowReferences
- Кремнева Е.И., Коновалов Р.Н., Кротенкова М.В. Функциональная магнитно-резонансная томография. Анн. клинич. и эксперим. неврол. 2011; 1: 30–39.
- Куликова С.Н. Куликова С.Н., Переседова А.В. и др. Динамическое исследование реорганизация коры и структуры проводящих путей при ремиттирующем рассеянном склерозе с парезом кисти. Анн. клинич. и эксперим. неврол. 2014; 1: 22–29.
- Селивёрстова Е.В., Селивёрстов Ю.А., Коновалов Р.Н., Иллариошкин С.Н. Функциональная магнитно-резонансная томография покоя: возможности метода и первый опыт применения в России. Анн. клинич. и эксперим. неврол. 2013; 4: 39–44.
- Balleine B.W. The neural basis of choice and decision making. J.Neurosci., 2007, 27: 8159–8160.
- Berthoud H.-R., Morrison C. The Brain, Appetite, and Obesity. Annu. Rev. Psychol., 2008, 59: 55–92.
- Carnell S., Gibson C., Benson L. et al. Neuroimaging and obesity: current knowledge and future directions. Obesity Reviews. 2011. doi: 10.1111/j.1467–789X.2011.00927.x.
- Ford E.S., Mokdad A.H. Epidemiology of obesity in Western Hemisphere. J. Clin. Endocrinol. Metab., 2008; 93: S1–S8.
- Friston K.J., Holmes A.P., Worsley K.J. et al. Statistical parametric maps in functional imaging: A general linear approach. Human Brain Mapping. 1995; 2 (4): 189–210.
- Mark A.L. Dietary therapy for obesity is failure and pharmacotherapy is the future: a point of view. Clin. Exp. Pharmacol. Physiol. 2006; 33:857–862.
- Murray E.A., O’Doherty J.P., Schoenbaum G. What we know and do not know about the functions of orbitofrontal cortex after 20 years of cross-species studies. J. Neurosci. 2007; 27: 8166–8169.
- Verhagen J.V. The neurocognitive bases of human multimodal food perception: consciousness. Brain Res. Rev. 2007; 53: 271–286.
- Waxman A., Norum K.R. Why a global strategy on diet, physical activity and health? The growing burden of non–communicable diseases. Public Health Nutr. 2004; 7: 381–383.
- Wing R.R., Papandonatos G., Fava J.L. et al. Maintaining large weight losses: the role of behavioral and psychological factors. J. Consult. Psychol. 2008; 76: 1015–1021.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).