PET-CT in early detection of Alzheimer’s disease: а case report

Semen V. Prokopenko; Прокопенко Семен В.; Boris V. Barankin; Баранкин Борис В.; Natal'ya М. Mar'ina; Марьина Наталья М.; Еlena Y. Mozheyko; Можейко Елена Ю.; Аnna F. Bezdenezhnykh; Безденежных Анна Ф.; Tat'yana D. Koryagina; Корягина Татьяна Д.; Natal'ya G. Chanchikova; Чанчикова Наталья Г.; Nikolay А. Tokarev; Токарев Николай А.; Еlena А. Karlova; Карлова Елена А.; Аnastasiya V. Ozerskaya; Озерская Анастасия В.; Еvgeniy А. Badrin; Бадрин Евгений А.; Кirill V. Belugin; Белугин Кирилл В.; Аnastasiya А. Savel'eva; Савельева Анастасия А.; Nikolay V. Shepelevich; Шепелевич Николай В.

doi:10.18454/ACEN.2017.4.7

PET-CT in early detection of Alzheimer’s disease: а case report

Authors: Prokopenko S.V.¹, Barankin B.V.², Mar'ina N.М.², Mozheyko Е.Y.¹, Bezdenezhnykh А.F.¹, Koryagina T.D.¹, Chanchikova N.G.², Tokarev N.А.², Karlova Е.А.², Ozerskaya А.V.², Badrin Е.А.², Belugin К.V.², Savel'eva А.А.², Shepelevich N.V.²
Affiliations:
1. Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky
2. Federal Siberian Research Clinical Center
Issue: Vol 11, No 4 (2017)
Pages: 65-70
Section: Clinical analysis
Submitted: 24.12.2017
Published: 27.12.2017
URL: https://www.annaly-nevrologii.com/journal/pathID/article/view/501
DOI: https://doi.org/10.18454/ACEN.2017.4.7
ID: 501

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Abstract

The article describes a clinical case of a female Alzheimer disease patient at an early stage of the neurodegenerative process. The patient did not have any complaints. She was taken to the neuropsychologist’s by her husband that was concerned because of the patient's family history (his mother-in-law suffered of Alzheimer's disease) and the emergence of some memory problems in his wife. The diagnosis was suspected based on the results of neuropsychological evaluation of cognitive functions which corresponded to mild cognitive impairment. To confirm the presence of a neurodegenerative disease brain positron-emission tomography with F-18 fluorodesoxyglucose (FDG) was performed. Hypometabolism of the imaging agent was detected in the temporal and parietal lobes cortex, in the association cortex of the left temporal and the right occipital lobes, and in the posterior part of the left cyngulate gyrus. This findings correlated with the data of the patient’s cognitive evaluation and thus provided the nosological diagnosis at an early stage of the disease.

Keywords

Alzheimer's disease, early detection, positron-emission tomography

References

Dierckx R.A.J.O., Otte A., de Vries E.F.J., Leenders K.L. (Eds.) PET and SPECT in Neurology. Berlin, Heidelberg: Springer-Verlag; 2014; 1074 p.
Luriya A.R. Vysshie korkovye funktsii i ikh narusheniya pri lokal'nykh porazheniyakh mozga. [Higher cortical functions and their disturbances in case of local brain lesions]. Moscow: Izd-vo MGU. 1962; 431 p. (In Russ.)
Damulin I.V. Kognitivnye rasstroystva. Nekotorye voprosy kliniki, diagnostiki, lecheniya. [Cognitive disorders. Aspects of the clinic, diagnosis, treatment]. Moscow: Meditsina, 2012. (In Russ.)
Yakhno N.N., Zakharov V.V., Lokshina A.B. et al. (Eds.) Dementsii : rukovodstvo dlya vrachey. [Dementia: a guide for doctors]. Moscow: MEDpress-inform. 2010; 264 p. (In Russ.)
McKhann G., Drachman D., Folstein M. et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 7 (34): 939-44. PMID: 6610841
Mirra S.S., Gearing M., McKeel D.W. et al. Interlaboratory comparison of neuropathology assessments in Alzheimer's disease : a study of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). J. Neuropathol. Exp. Neurol. 1994; 3 (53): 303-15. PMID: 8176413
Gavrilova S.I. Psikhicheskie rasstroystva pri pervichnykh degenerativnykh (atroficheskikh) protsessakh golovnogo mozga. [Mental disorders in the primary degenerative (atrophic) processes of the brain]. In: Manual of Psychiatry. Ed.: A.S. Tiganova. – Moscow: Meditsina, 1999: 57-117. (In Russ.)
Ishii K. PET Approaches for Diagnosis of Dementia. Am J Neuroradiol 2014; 35(11): 2030-8. doi: 10.3174/ajnr.A3695. PMID: 23945233
Shivamurthy V.K., Tahari A.K., Marcus C., Subramaniam R.M. Brain FDG PET and the Diagnosis of Dementia. American Journal of Roentgenology. 2015;204: W76-W85. PMID: 25539279 doi: 10.2214/AJR.13.12363
Kondakov A.K., Znamenskiy I.A., Mosin D.Yu. Et al. [The possibilities of nuclear medicine in the diagnosis of dementia]. Vestnik RGMU 2016; 6: 43-47. (In Russ.)
Karow D.S., McEvoy L.K., Fennema-Notestine C. et al. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010; 256: 932– 42. PMID: 16550383 doi: 10.1007/s00259-005-0050-x
Kawachi T., Ishii K., Sakamoto S. et al. Comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2006; 33: 801–09. PMID: 16550383 doi: 10.1007/s00259-005-0050-x
Matsunari I., Samuraki M., Chen W.P. et al. Comparison of 18F-FDG PET and optimized voxel-based morphometry for detection of Alzheimer’s disease: aging effect on diagnostic performance. J Nucl Med. 2007; 48: 1961–70. PMID: 19001534 doi: 10.3174/ajnr.A1357
Yuan Y., Gu Z.X., Wei W.S. Fluorodeoxyglucose-positron-emission tomography, single-photon emission tomography, and structural MR imaging for prediction of rapid conversion to Alzheimer disease in patients with mild cognitive impairment: a meta-analysis. AJNR Am J Neuroradiol. 2009; 30: 404–10. PMID: 19001534 doi: 10.3174/ajnr.A135

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PET-CT in early detection of Alzheimer’s disease: а case report

Full Text

Abstract

Keywords

About the authors

References

Supplementary files

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