Endogenous retrovirus: from fundamental studies to etiotropic therapy of multiple sclerosis
- Authors: Zakharova M.N.1, Logunov D.Y.2, Kochergin I.A.1, Bakulin I.S.1
-
Affiliations:
- Research Center of Neurology
- N.F. Gamaleya Research Institute of Epidemiology and Microbiology
- Issue: Vol 9, No 4 (2015)
- Pages: 49-53
- Section: Reviews
- Submitted: 31.01.2017
- Published: 07.02.2017
- URL: https://www.annaly-nevrologii.com/journal/pathID/article/view/80
- DOI: https://doi.org/10.17816/psaic80
- ID: 80
Cite item
Full Text
Abstract
Retroviruses are a single-stranded RNA viruses that introduce their genes into host cells genome. Genes of retroviruses compose 9.3% of human genome. These genes may influence human genome activity by changing its structure and stability, introducing regulatory elements and expression of retroviral genes. Recently role of endogen retroviruses in human disease is studied. This article presents an overview of the role of retroviruses in the development of multiple sclerosis and potential approaches to etiotropic therapy.
About the authors
Maria N. Zakharova
Research Center of Neurology
Email: bakulin@neurology.ru
Russian Federation, Moscow
D. Y. Logunov
N.F. Gamaleya Research Institute of Epidemiology and Microbiology
Email: bakulin@neurology.ru
Russian Federation, Moscow
I. A. Kochergin
Research Center of Neurology
Email: bakulin@neurology.ru
Russian Federation, Moscow
Ilya S. Bakulin
Research Center of Neurology
Author for correspondence.
Email: bakulin@neurology.ru
ORCID iD: 0000-0003-0716-3737
Cand. Sci. (Med.), researcher, Department of neurorehabilitation and physiotherapy
Russian Federation, MoscowReferences
- Andersson M.L., Lindeskog M., Medstrand P. et al. Diversity of human endogenous retrovirus class II-like sequences. J Gen Virol. 1999; 80 (1): 255–260.
- Antony J.M., van Marle G., Opii W. et al. Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nat Neurosci. 2004; 7(10): 1088–1095.
- Antony J.M., Zhu Y., Izad M. et al. Comparative expression of human endogenous retrovirus-W genes in multiple sclerosis. AIDS Res Hum Retroviruses. 2007; 23 (10): 1251–1256.
- Balada E., Vilardell-Tarrés M., Ordi-Ros J. Implication of human endogenous retroviruses in the development of autoimmune diseases. Int Rev Immunol. 2010; 29 (4): 351–370.
- Christensen T., Tönjes R.R., zur Megede J. et al. Reverse transcriptase activity and particle production in B lymphoblastoid cell lines established from lymphocytes of patients with multiple sclerosis. AIDS Res Hum Retroviruses. 1999; 15(3): 285 015—91.
- Christensen T. HERVs in neuropathogenesis. J Neuroimmune Pharmacol. 2010; 5 (3): 326–335.
- Clausen J. Endogenous retroviruses and MS: using ERVs as disease markers. Int MS J. 2003; 10 (1): 22–28.
- Curtin F., Perron H., Faucard R. et al. Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis. Mol Diagn Ther. 2015; 19 (5): 255–265.
- Derfuss T., Curtin F., Guebelin C. et al. A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients – a twelve month follow-up. J Neuroimmunol. 2015; 285: 68–70.
- Dolei A., Perron H. The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease. J Neurovirol. 2009; 15 (1): 4–13.
- Douville R.N., Nath A. Human endogenous retroviruses and the nervous system. Handb Clin Neurol. 2014; 123: 465–485.
- Emmer A., Staege M.S., Kornhuber M.E. The retrovirus/superantigen hypothesis of multiple sclerosis. Cell Mol Neurobiol. 2014;34 (8):1087–1096.
- Garson J.A., Tuke P.W., Giraud P. et al. Detection of virion-associated MSRV-RNA in serum of patients with multiple sclerosis. Lancet. 1998; 351 (9095): 33.
- Hon G.M., Erasmus R.T., Matsha T. et al. Multiple sclerosis-associated retrovirus and related human endogenous retrovirus-W in patients with multiple sclerosis: a literature review. J Neuroimmunol. 2013; 263 (1–2): 8–12.53
- Kudo Y., Boyd C.A., Sargent I.L., Redman CW. Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia. Biochim Biophys Acta. 2003; 1638 (1): 63–71.
- Mameli G., Madeddu G., Mei A. et al. Activation of MSRV-type endogenous retroviruses during infectious mononucleosis and EpsteinBarr virus latency: the missing link with multiple sclerosis? PLoS One. 2013; 8 (11): e78474.
- Mameli G., Poddighe L., Mei A. et al. Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis. PLoS One. 2012; 7 (9): e44991.
- Martin M.A., Bryan T., Rasheed S. et al. Identification and cloning of endogenous retroviral sequences present in human DNA. Proc Natl Acad Sci U S A. 1981; 78 (8): 4892–4896.
- Moyes D., Griffiths D.J., Venables P.J. Insertional polymorphisms: a new lease of life for endogenous retroviruses in human disease. Trends Genet. 2007; 23 (7): 326–333.
- Nissen K.K., Laska M.J., Hansen B. et al. Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle. BMC Neurol. 2013; 13: 111.
- Perron H., Garson J.A., Bedin F. et al. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis. Proc Natl Acad Sci U S A. 1997; 94 (14): 7583–7588.
- Rolland A., Jouvin-Marche E., Saresella M. et al. Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in patients with multiple sclerosis. J Neuroimmunol. 2005; 160 (1–2): 195–203.
- Saresella M., Rolland A., Marventano I. et al. Multiple sclerosisassociated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis. Mult Scler. 2009; 15 (4): 443–447.
- Suntsova M., Garazha A., Ivanova A. et al. Molecular functions of human endogenous retroviruses in health and disease. Cell Mol Life Sci. 2015; 72 (19): 3653–3675.
- Serra C., Sotgiu S., Mameli G. et al. Multiple sclerosis and multiple sclerosis-associated retrovirus in Sardinia. Neurol Sci. 2001; 22 (2):171–173.
- Serra C., Mameli G., Arru G. et al. In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis. J Neurovirol. 2003; 9 (6): 637–643.