Endogenous retrovirus: from fundamental studies to etiotropic therapy of multiple sclerosis

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Abstract

Retroviruses are a single-stranded RNA viruses that introduce their genes into host cells genome. Genes of retroviruses compose 9.3% of human genome. These genes may influence human genome activity by changing its structure and stability, introducing regulatory elements and expression of retroviral genes. Recently role of endogen retroviruses in human disease is studied. This article presents an overview of the role of retroviruses in the development of multiple sclerosis and potential approaches to etiotropic therapy.

About the authors

Maria N. Zakharova

Research Center of Neurology

Email: bakulin@neurology.ru
Russian Federation, Moscow

D. Y. Logunov

N.F. Gamaleya Research Institute of Epidemiology and Microbiology

Email: bakulin@neurology.ru
Russian Federation, Moscow

I. A. Kochergin

Research Center of Neurology

Email: bakulin@neurology.ru
Russian Federation, Moscow

Ilya S. Bakulin

Research Center of Neurology

Author for correspondence.
Email: bakulin@neurology.ru
ORCID iD: 0000-0003-0716-3737

Cand. Sci. (Med.), researcher, Department of neurorehabilitation and physiotherapy

Russian Federation, Moscow

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Copyright (c) 2015 Zakharova M.N., Logunov D.Y., Kochergin I.A., Bakulin I.S.

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