Navigated repetitive transcranial magnetic stimulation in post-stroke rehabilitation: a randomized, double-blind, sham-controlled study

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Abstract

Navigated rTMS is characterized by a great accuracy of localizing the stimulated area, which opens up new prospects for neuroplasticity modulation. We conducted an interventional randomized double-blind sham-controlled study to evaluate the effectiveness of navigated rTMS in post-stroke rehabilitation. We found that low-frequency stimulation reliably reduces severity of motor deficit and increases the Barthel Index of Activities of Daily Living. High-frequency stimulation reduces spasticity (Ashworth Scale) and severity of central post-stroke pain syndrome. Navigated repetitive transcranial magnetic stimulation effectively supplements the conventional rehabilitation of poststroke patients. Compared to routine TMS, the use of navigated rTMS enables effective control of the neuroplastic processes and provides new opportunities in development of personalized neurorehabilitation programs.

About the authors

A. V. Chervyakov

Research Center of Neurology

Email: nasu2709@mail.ru
Russian Federation, Moscow

Alexandra G. Poydasheva

Research Center of Neurology

Email: nasu2709@mail.ru
ORCID iD: 0000-0003-1841-1177

junior researcher, neurologist, Department of neurorehabilitation and physiotherapy

Russian Federation, Moscow

M. А. Nazarova

Research Center of Neurology

Email: nasu2709@mail.ru
Russian Federation, Moscow

V. V. Gnezditsky

Research Center of Neurology

Email: nasu2709@mail.ru
Russian Federation, Moscow

Natalya A. Suponeva

Research Center of Neurology

Email: nasu2709@mail.ru
ORCID iD: 0000-0003-3956-6362

D. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, principal researcher, Department of neurorehabilitation and physiotherapy

Russian Federation, Moscow

L. A. Chernikova

Research Center of Neurology

Email: nasu2709@mail.ru
Russian Federation, Moscow

Mikhail A. Piradov

Research Center of Neurology

Author for correspondence.
Email: nasu2709@mail.ru
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

Russian Federation, Moscow

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Copyright (c) 2015 Chervyakov A.V., Poydasheva A.G., Nazarova M.А., Gnezditsky V.V., Suponeva N.A., Chernikova L.A., Piradov M.A.

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