Neuroprotection in cerebrovascular diseases: is it the search for life on Mars or a promising trend of treatment? Part 1. Acute stroke
- Authors: Piradov M.A.1, Tanashyan M.M.1, Domashenko M.A.1, Sergeev D.V.1, Maksimova M.Y.1
-
Affiliations:
- Research Center of Neurology
- Issue: Vol 9, No 1 (2015)
- Pages: 41-50
- Section: Reviews
- Submitted: 01.02.2017
- Published: 10.02.2017
- URL: https://www.annaly-nevrologii.com/journal/pathID/article/view/154
- DOI: https://doi.org/10.17816/psaic154
- ID: 154
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Abstract
The two key strategies of specific treatment of stroke are reperfusion, aimed on the improvement of brain perfusion in the ischemic region due to the restoration of blood flow and prevention of recurrent thrombosis, and neuroprotection to maintain brain tissue metabolism and to protect it from structural damage. The evidential base of major neuroprotective drugs (nimodipine, magnesium sulfate, piracetam, ethylmethylhydroxypyridine succinate, choline alfoscerate, cerebrolysin, albumin, citicoline, edaravone) and hypothermia use in acute stroke setting is critically reviewed in the article.
Keywords
About the authors
Mikhail A. Piradov
Research Center of Neurology
Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-6338-0392
D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director
Russian Federation, MoscowMarine M. Tanashyan
Research Center of Neurology
Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-5883-8119
D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department
Russian Federation, MoscowM. A. Domashenko
Research Center of Neurology
Email: ncnmaximova@mail.ru
Russian Federation, Moscow
Dmitry V. Sergeev
Research Center of Neurology
Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-9130-1292
Cand. Sci. (Med.), neurologist, Neurorehabilitation department with TMS group
Russian Federation, 125367, Russia, Moscow, Volokolamskoye shosse, 80Marina Yu. Maksimova
Research Center of Neurology
Author for correspondence.
Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-7682-6672
D. Sci. (Med), Prof., Head, 2nd Neurology department
Russian Federation, 125367 Moscow, Volokolamskoye shosse, 80; MoscowReferences
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