Multicentral pilot clinical trial of gliatilin in treatment of acute ischemic stroke
- Authors: Odinak M.M.1, Voznyuk I.A.1, Piradov M.A.2, Rumyantseva S.A.3, Kuznetsov A.N.4, Yanishevskiy S.N.5, Golokhvastov S.Y.5, Tsygan N.V.5
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Affiliations:
- S.M. Kirov Military Medical Academy
- Research Center of Neurology
- Clinical hospital № 15
- National medico-surgical center of N.I. Pirogov
- Military Medical Academy
- Issue: Vol 4, No 1 (2010)
- Pages: 20-28
- Section: Original articles
- Submitted: 03.02.2017
- Published: 13.02.2017
- URL: https://www.annaly-nevrologii.com/journal/pathID/article/view/352
- DOI: https://doi.org/10.17816/psaic352
- ID: 352
Cite item
Full Text
Abstract
The multicentral pilot clinical trial of gliatilin in treatment of acute ischemic stroke was held in 2006–2008 in Russia. The trial involved 122 patients, who received basic treatment and gliatilin during 3 months after the stroke onset (1–15 days – 2000 mg per day, 16–30 days – 1000 mg per day, 31–90 days – 800 mg per day). All patients underwent clinical examination (including repeated NIHSS, Rankin scale, Barthel index assessment), laboratory and ultrasound examination, computer tomography or magnetic resonance imaging during 24 hours after the stroke onset. 25 patients underwent repeated multimodal magnetic resonance imaging (T1-, T2-, diffusion-, perfusion-weighted imaging). The results of examination of patients who received basic treatment alone were taken from literature. The trial results show, that treatment of acute ischemic stroke with gliatilin promotes neurological recovery and increase of patient’s self-care ability, which is probably concerned with the smaller final volume of brain infarct.
About the authors
Miroslav M. Odinak
S.M. Kirov Military Medical Academy
Email: voznjouk@yandex.ru
Россия, St. Petersburg
Igor A. Voznyuk
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: voznjouk@yandex.ru
ORCID iD: 0000-0002-0340-4110
D. Sci. (Med.), Professor, Department of Neurology, First Pavlov State Medical University; Professor, Department of Nervous Diseases, S.M. Kirov Military Medical Academy
Россия, St. PetersburgMikhail A. Piradov
Research Center of Neurology
Email: voznjouk@yandex.ru
ORCID iD: 0000-0002-6338-0392
D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director
Россия, MoscowS. A. Rumyantseva
Clinical hospital № 15
Email: voznjouk@yandex.ru
Россия, Moscow
A. N. Kuznetsov
National medico-surgical center of N.I. Pirogov
Email: voznjouk@yandex.ru
Россия, Moscow
S. N. Yanishevskiy
Military Medical Academy
Email: voznjouk@yandex.ru
Россия, Saint Petersburg
S. Yu. Golokhvastov
Military Medical Academy
Email: voznjouk@yandex.ru
Россия, Saint Petersburg
N. V. Tsygan
Military Medical Academy
Email: voznjouk@yandex.ru
Россия, Saint Petersburg
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