A role of genetic factors in the development of individual predisposition to ischemic stroke

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Abstract

Intensive development of DNA analysis technologies and largescale genome-wide association studies have led to accumulation of a large array of data on the relationship between genetic factors and various phenotypic manifestations, including monogenic and polygenic hereditary diseases. This greatly has extended the capabilities of clinical diagnostics and predictive medicine in the field of socially significant diseases. For example, a role of a genetic component of the risk for such a multifactorial and polyetiologic disease as stroke is now actively explored. Large-scale studies have revealed both general and specific genetic markers associated only with a certain type and subtype of stroke. This review analyzes the current state of the problem of using genetic markers for diagnosis of stroke predisposition, complex issues associated with multiplicity of risk factors for stroke, and possible development in this area.

About the authors

V. I. Korchagin

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Russian Federation, Moscow

K. O. Mironov

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Russian Federation, Moscow

O. P. Dribnokhodova

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Russian Federation, Moscow

Marina Yu. Maksimova

Research Center of Neurology, Moscow

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-7682-6672
Russian Federation, Moscow, Volokolamskoe shosse,80

Sergey N. Illarioshkin

Research Center of Neurology

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-2704-6282

D. Sci. (Med.), Prof., Corr. Member of the Russian Academy of Sciences, Deputy Director, Head, Department for brain research

Russian Federation, Moscow

Marine M. Tanashyan

Research Center of Neurology

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department

Russian Federation, Moscow

A. E. Platonov

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Russian Federation, Moscow

G. A. Shipulin

Central Research Institute of Epidemiology

Email: vitaly_korchagin@rambler.ru
Russian Federation, Moscow

Anton A. Raskurazhev

Research Center of Neurology

Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0003-0522-767X

Cand. Sci. (Med.), neurologist, researcher, 1st Neurology department

Russian Federation, Moscow

Mikhail A. Piradov

Research Center of Neurology

Author for correspondence.
Email: vitaly_korchagin@rambler.ru
ORCID iD: 0000-0002-6338-0392

D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director

Russian Federation, Moscow

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Copyright (c) 2016 Korchagin V.I., Mironov K.O., Dribnokhodova O.P., Maxsimova M.Y., Illarioshkin S.N., Tanashyn M.M., Platonov A.E., Shipulin G.A., Raskurazhev A.A., Piradov M.A.

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